基本信息

• 商品名稱：Epigenetics in Cancer
• 作者：編者:JUNJIANG FU//SABER IMANI
• 定價：198
• 齣版社：科學
• ISBN號：9787030543769

其他參考信息（以實物為準）

• 齣版時間：2018-01-01
• 印刷時間：2018-01-01
• 版次：1
• 印次：1
• 開本：16開
• 包裝：平裝
• 頁數：364

內容提要

《Epigenetics in Cancer》由JUNJIANG FU、 SABER IMANI著。
     As the second leading cause of death, cancer has casted an overwhelming shadow on millions of life worldwide. Everyone is affected in some way, if not by having the disease themselves, then by witnessing it in friends or loved ones. The book titled Epigenetics in Cancer, addresses the importance of fighting cancers with an epigenetics approach. Specifically, the following topics are reviewed: (1) DNA methylation and cancer; (2) Non-coding RNAs in cancer; (3) Epigenetics in the diagnosis, prognosis, and therapy of cancer; (4) Epigenetic effects of environmental and dietary factors in cancer. The book also includes a chapter that provides short but practical protocols widely used in epigenetics research. Finally, it provides insight into future directions in cancer epigenetics research. Thus, this book covers a wide range of topics, from general mechanisms of cancer epigenetics to cancer therapy. This book to be helpful to improve their understanding of epigenetics and cancer who are interested in cancer epigenetics and the development of anticancer drugs at various levels, including students in medical and biological fields, postdoctoral fellows, university researchers, and/or educators.

目錄

Chapter 1: Overview of Epigenetics
1.1 Introduction
1.2 Specific epigenetic modifications
1.3 DNA methylation in cancer
1.4 Post-translational histone modifications
1.5 Non-coding RNAs
1.6 Chromatin remodelling
1.7 Histone variants
1.8 Long range epigenetic alterations
1.9 Mutations in epigenetic modifiers in cancer
1.10 Clinical implications of aberrant epigenetic control
1.11 Future directions in epigenetic cancer research
1.12 Acknowledgments
1.13 References
Chapter 2: DNA Methylation and Cancer
2.1 Introduction
2.2 Mechanisms of DNA methylation
2.3 DNA methylation assay
2.4 DNA hypomethylation in cancers
2.5 DNA hypermethylation in cancers
2.6 Epigenetic therapy
2.7 Conclusion
2.8 References
Chapter 3: Non-coding RNAs in Cancer
3.1 Overview
3.2 RNA regulatory mechanisms
3.3 MicroRNAs and cancer
3.4 Long non-coding RNAs (lncRNAs) and cancer
3.5 Short interfering (siRNA) and cancer
3.6 PIWI-interacting RNAs (piRNAs) and cancer
3.7 CircRNAs and cancer
3.8 Non-coding RNAs in cancer
3.9 Diagnostics, prognosis, and therapeutics challenges ofncRNAs
3.10 Conclusion & future perspectives
3.11 References
Chapter 4: Chromatin Remodeling and Cancer
4.1 Introduction
4.2 The concept of chromatin remodeling
4.3 Histone variants
4.4 Chromatin remodeling during DNA replication
4.5 Chromatin remodeling during DNA repair
4.6 The role of remodelers in recruitment and transcription initiation
4.7 Post-translational modifications ofremodelers
4.8 ATP-dependent chromatin remodeling in cancer
4.9 Perspectives
4.10 References
Chapter 5: Epigenetic Therapy of Cancer-From Mechanisms to Clinical Utility...
5.1 Introduction
5.2 Overview of epigenetic modifications as potential therapeutic targets in cancer
5.3 Epigenetic therapy of cancer
5.4 Conclusions and future perspectives of epigenetic therapy
5.5 References
Chapter 6: Epigenetic Effects of Environmental and Dietary Factors in Cancer Development and Bioethical Implications
6.1 Introduction
6.2 Environmental factors and epigenetics in carcinogenesis
6.3 Endocrine disrupting chemicals
6.4 Eppigenetic effects of lifestyle and dietary factors on cancers
6.5 Ethical implications of environmental epigenetics
6.6 Bioinformatics approach in the environmental epigenetics
6.7 Conclusions and future perspectives
6.8 References
Chapter 7: Main Protocols in Cancer Epigenetics
Protocol 1 MiRNA extract and stem-loop RT-qPCR
Protocol 2 Protein complex purification from Flp-InTM T-RExTM 293 stably expressed FLAG tagged protein cell line
Protocol 3 ChiP-Sequencing from Flp-InTM T-RExTM 293 stably expressed FLAG tagged protein cell lines
Protocol 4 ChiP assay for endogenous gene
Protocol 5 The cancer cell index, migration, and invasion assays
Color Figures