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　　《分子生物學：從基因到蛋白質（第3版）（影印版）》前兩版書名是《分子生物學》，分彆在1983年和1987年齣版，由先後在Brandeis大學和加州大學聖地亞哥分校教授生物化學和分子生物學課程的DavidFreifelder教授編寫並修訂的。

目錄

Preface

CHAPTER 1 Introduction to Molecular Biology

SECTION 1 Protein Structure and Function

CHAPTER 2 Protein Structure

CHAPTER 3 Protein Function



SECTION 2 Nucleic Acids and Nucleoproteins

CHAPTER 4 Deoxyribonucleic Acid Structure

CHAPTER 5 Nucleic Acid Technology

CHAPTER 6 Chromosome Structure



SECTION 3 Genetics and Virology

CHAPTER 7 Genetic Analysis in Molecular Biology

CHAPTER 8 Viruses in Molecular Biology



SECTION 4 DNA Metabolism

CHAPTER 9 DNA Replication

CHAPTER 10 DNA Damage and Repair

CHAPTER 11 Recombination

CHAPTER 12 Transposons and Other Mobile Elements



SECTION 5 RNA Synthesis and Processing

CHAPTER 13 Bacterial RNA Polymerase

CHAPTER 14 Regulation of Bacterial Gene Transcription

CHAPTER 15 RNA Polymerase Ⅱ: Basal Transcription

CHAPTER 16 RNA Polymerase Ⅱ: Regulation

CHAPTER 17 RNA Polymerase Ⅱ: Cotranscriptional and Posttranscriptional Processes

CHAPTER 18 Ribosomal RNA, Transfer RNA, and Organellar RNA Synthesis



SECTION 6 Protein Synthesis

CHAPTER 19 Protein Synthesis: The Genetic Code

CHAPTER 20 Protein Synthesis: The Ribosome

Index

精彩書摘

　　These nucleases, which were called restriction endonudeasesbecause they blocked or restricted viral replication, act only on DNAwith specific recognition sequences and only when the recognition sequences are not modified. Host DNA is protected because it has methylgroups attached to specific bases within the recognition sequence.

　　Three major types of restrictionmodification systems have beenstudied （Table S.2）. Type I restrictionmodification systems consist offive polypeptide subunits: two identical restriction endonuclease subunits （R）, two identical modification subunits （M）, and a specificitysubunit （S）. If the sequence that is recognized by the specificity subunitdoes not have a methyl group, then one of two things will happen. Themodification subunits will methylate the sequence and the DNA willbe protected, or the restriction subunits will cleave the DNA at a nonspecific site, often I kb or more from the recognition sequence, and theDNA will be degraded. Type II restrictionmodification systems aremade of two independent enzymes, a homodimeric restriction endonuclease and a monomeric methyl transferase （methylase）. Type 1I restrictionmodification enzymes recognize sequences that are 4 to 8 bp long.Type II methylases transfer methyl groups to bases within the recognition sequence and type II endonucleases cleave DNA within the recognition sequence. Type III restrictionmodification systems consist oftwo subunits, a modification subunit and a restriction subunit. Modification occurs within the recognition sequence but cleavage takesplace about 25 bp away from this site. The discussion that follows islimited to the type II endonucleases because they are the only one of thethree types that has been widely used to manipulate DNA.

前言/序言

　　在上個世紀，1953年DNA雙螺鏇結構的解析和1956年中心法則的成形宣告著分子生物學時代的到來。分子生物學憑其影響力的自然滲透和許多科學傢幾十年的辛勤耕耘成為生命科學的基石學科。52年後的今天，定義遺傳物質流動方嚮的中心法則仍然是分子生物學的框架，即遺傳物質通過DNA復製來實現傳代，通過轉錄閤成RNA，再通過翻譯從mRNA閤成蛋白質。當然，現代的分子生物學教材都會加入基因錶達的調控和分子生物學方法的相關內容。另外，有許多分子生物學教材會以介紹生物活性大分子蛋ca質和核酸的結構為開胃菜，這兩類大分子是所有分子生物學事件的主要執行者。

　　《分子生物學——從基因到蛋白質》前兩版書名是《分子生物學》，分彆在1983年和1987年齣版，由先後在Brandeis大學和加州大學聖地亞哥分校教授生物化學和分子生物學課程的DavidFreifelder教授編寫並修訂的。《分子生物學——從基因到蛋白質》第3版是由紐約城市大學皇後學院的BurtonE．Tropp教授編寫的，具有以下4個主要特色：

　　1．基礎性強。翔實全麵

　　該書共包括六部分20章。第一到第三部分共8章是引導性基礎知識：包括蛋白質的結構和功能；核酸結構、核酸技術和染色體結構；遺傳分析及病毒對分子生物學的貢獻和地位。第四到第六部分共12章是分子生物學的核心內容：包括DNA代謝（DNA復製，DNA損傷和修復，DNA重組和轉座），RNA的閤成和加工（細菌內的轉錄和基因錶達調控，真核細胞內mRNA轉錄、調控和轉錄後加工，核糖體RNA、轉運RNA和細胞器RNA的閤成），以及蛋白質的閤成（轉運RNA和遺傳密碼，核糖體和翻譯過程）。該書對所涉及內容的描述非常傘麵翔實，並具有一定的前沿性，非常適用於初學者。



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